Operated by and occupying the same space as Hotel Palazzo Guadagni, you get enormous rooms and an enviably central location at Santo Spirito. The rooms in this converted mansion are individually decorated, with TV, air conditioning, free wi-fi, mini-bar, and bathrooms with bathtubs. Some of the rooms boast original ceiling frescoes. The guesthouse’s long, private loggia (like a covered balcony) is an ideal place for drinks and sweeping views of the piazza, basilica, Pitti Palace and the Duomo. Breakfast is included.

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  Photo by Leif Pettersen
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  Photo by Leif Pettersen
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  Photo by Leif Pettersen
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  Photo by Leif Pettersen
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  Photo by Leif Pettersen
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  Photo by Leif Pettersen
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  Photo by Leif Pettersen
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  Photo by Leif Pettersen